Tuberculosis is a major global public health challenge, and a majority of countries have adopted a version of the global strategy to fight Tuberculosis, Directly Observed Treatment, Short Course (DOTS). Drawing on results from research in Ethiopia and Norway, the aim of this paper is to highlight and discuss ethical aspects of the practice of Directly Observed Treatment (DOT) in a cross-cultural perspective.

There is a standard story told about the rise and fall of ordinary language philosophy: it was a widespread, if not dominant, approach to philosophy in Great Britain in the aftermath of World War II up until the early 1960s, but with the development of systematic approaches to the study of language—formal semantic theories on one hand and Gricean pragmatics on the other—ordinary language philosophy more or less disappeared. In this paper we present quantitative evidence to evaluate the standard story (...) of the rise and fall of ordinary language philosophy, building on the topic model of over 30,000 philosophy articles in Weatherson (2022). Using a combination of qualitative judgment and a topic-model-based measurement of similarity between individual articles, we find evidence that supports the first part of the standard story, according to which ordinary language philosophy arises in the 1940s, peaks between the early 1950s and the late 1960s, and then rapidly declines. But we argue that there is also evidence of a "new wave" of ordinary language philosophy in the early 21st century that defies the second part of the standard story. (shrink)

We investigate claims about the frequency of "know" made by philosophers. Our investigation has several overlapping aims. First, we aim to show what is required to confirm or disconfirm philosophers’ claims about the comparative frequency of different uses of philosophically interesting expressions. Second, we aim to show how using linguistic corpora as tools for investigating meaning is a productive methodology, in the sense that it yields discoveries about the use of language that philosophers would have overlooked if they remained in (...) their "armchairs of an afternoon", to use J.L. Austin’s phrase. Third, we discuss facts about the meaning of "know" that so far have been ignored in philosophy, with the aim of reorienting discussions of the relevance of ordinary language for philosophical theorizing. (shrink)

Preparing the Next Generation of Oral Historians is an invaluable resource to educators seeking to bring history alive for students at all levels. Filled with insightful reflections on teaching oral history, it offers practical suggestions for educators seeking to create curricula, engage students, gather community support, and meet educational standards. By the close of the book, readers will be able to successfully incorporate oral history projects in their own classrooms.

ABSTRACT Objective: To describe how local research ethics committees (LRECs) consider and apply research ethics in the evaluation of biomedical research proposals. Design: A qualitative study was conducted using purposeful sampling, focus groups and a grounded theory approach to generate data and to analyse the work of the LRECs. Setting and participants: 11 LRECs of the Mexican Institute of Social Security (IMSS). Results: LRECs considered ethics to be implicit in all types of research, but that ethics reviews were only necessary (...) for projects that included the direct participation of human beings. The LRECs appeared to understand the importance of consent, as in the completion of a consent form, but did not emphasise the importance of the process of acquiring ‘informed’ consent. The committees considered their main roles or functions to be: (a) to improve the methodological quality of research and to verify – if applicable – the ethical aspects; (b) to encourage personnel to undergo research training; (c) to follow‐up research to oversee the adherence to norms and compliance with a specified research timetable. Conclusions: This study provides a valuable insight into how these LRECs understand the ethical review process. The emphasis of the committees was on rules, regulations, improving research methodology and research training, rather than a focus on efforts to protect the rights and well being of research subjects. The results encourage further normative and descriptive lines of investigation concerning education and the development of LRECs. (shrink)

It is a great privilege to have been invited to speak on this occasion. I shall not talk about Janet Semple's life, since I did not know Janet Semple well. I first came across her work when the Oxford University Press sent me a copy of her Ph.D. thesis, asking for my opinion as to its publishability. I groaned—yet another study of the panopticon! I opened it, started reading—and read it straight through. It was so clear, insightful, powerful in its (...) interpretation and beautifully written. I am delighted to see that it has appeared as Bentham's Prison. I was, at a later stage, equally pleased to be involved in persuading Janet to publish some of her research on Bentham's medical and health interests. I shall not try to evaluate her work today. I think I might best honour her by trying to reflect upon some of the wider issues that surround Bentham's concerns with prisons and hospitals—issues raised by her work. (shrink)

Les algèbres de dimensions supérieures libèrent les mathématiques de la restriction d'une notation purement linéaire. Elles aident ainsi à la modélisation de la géométrie et procurent une meilleure compréhension et plus de possibilités pour les calculs. Elles nous donnent de nouveaux outils pour l'étude de problèmes non-commutatifs, de dimension supérieure qui assurent le passage du local au global, en utilisant la notion d' «inverse algébrique de subdivision». Nous allons exposer comment ces idées sont venues aux auteurs en prolongeant initialement la (...) notion classique de groupe abstrait à celle de groupoïde abstrait, dont la composition n'est que partiellement définie, et qui ajoute une composante spatiale à la théorie habituelle des groupes. La théorie des noeuds nous fournit un exemple en indiquant comment une telle algèbre peut être utilisée pour décrire la structure d'un espace. Le prolongement à la dimension 2 utilise des compositions de carrés dans deux directions et la richesse de l'algèbre qui en résulte est montrée par certains calculs de dimension 2. La difficulté de la transition de la dimension 1 à la dimension 2 est également illustrée par la comparaison de la notion de carré commutatif à celle de cube commutatif - le traitement de cette dernière nécessitant de nouvelles notions. L'importance de la théorie des catégories est expliquée, de même que les possibilités de l'application d'algèbres de dimensions supérieures. (shrink)

Rewriting the Self is an exploration of ideas of the self in the western cultural tradition from the Renaissance to the present. The contributors analyze different religious, philosophical, psychological, political, psychoanalytical and literary models of personal identity from a number of viewpoints, including the history of ideas, contemporary gender politics, and post-modernist literary theory. Challenging the received version of the "ascent of western man," they assess the discursive construction of the self in the light of political, technological and social changes. (...) Contributors include: Peter Burke, Roger Cardinal, Stephen Connor, Jonathan Dollimore, Terry Eagleton, Kate Flint, E.J. Hundert, John Mullan, Linda Nead, Daniel Pick, Nikolas Rose, Jonathan Sawday, Jane Shaw, Roger Smith, Sylvana Tomaselli and Carolyn D. Williams. (shrink)

L'article retrace l'histoire de l'image du peuple de Dieu comme brebis et pasteur dans l'Ecriture, dans deux figures représentatives de l'époque patristique, Augustin d'Hyppone et Grégoire de Nazianze, ainsi que dans la Constitution Dogmatique sur l'Eglise dans le Second Concile du Vatican. L'article fait une application précise de cette image au phénomène contemporain d'un changement culturel rapide dans le monde et dans l'Eglise. L'article soutient que l'image biblique des brebis et du pasteur ne doit pas être abandonnée comme un pûr (...) artifice culturel qui reflète une structure sociale primitive désormais entièrement désuète. Plutôt, cette image est une affirmation vitale et importante, tant anthropologique que ecclésiologique, sur la nature humaine, le besoin humain de communauté, d'autorité, de direction et d'attention. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Protecting Human Research SubjectsThe Office for Protection from Research RisksJoan Paine Porter (bio)The office for Protection from Research Risks (OPRR), located within the National Institutes of Health, has two divisions: Human Subject Protections and Animal Welfare. This article will address the overall responsibilities and current projects relating to human subject protections.OPRR implements the Department of Health and Human Services' (HHS) regulations for the protection of human subjects (45 (...) CFR 46 (1991)). These regulations fulfill the responsibilities set forth in the Public Health Service (PHS) Act with regard to institutional review boards (IRB) and other protections for human subjects involved in biomedical and behavioral research conducted or supported by HHS. The PHS Act also mandates a program to clarify ethical issues in biomedical research involving human subjects and to address violations of the rights of human subjects of research (P.L. 99-158 (1985)).OPRR staff negotiate assurances of compliance with institutions conducting Federally-supported research involving human subjects. The assurances describe the policies and procedures each institution will follow to fulfill the requirements of the regulations, including specific IRB composition and functions.In addition, OPRR cosponsors with the Food and Drug Administration and awardee institutions a series of regional workshops that address human subject protections issues. These are attended by IRB members, institutional officials, research investigators, and others involved with human subject protections.Current ActivitiesNumerous activities are underway in OPRR. The following describes only a few of the initiatives and studies aimed at helping develop policies and procedures to protect human subjects of research."Points to Consider" DocumentsOPRR is currently working with the National Center for Human Genome Research (NCHGR) to develop a "points to consider" document for IRBs and others involved in large genetic pedigree studies. Many questions have emerged [End Page 279] on topics such as how subjects should be recruited, with whom information should be shared about others in the family, social risks of disclosure in employment and insurance, the circumstances and timing of informing subjects about study results, and involvement of children. OPRR and NCHGR hope to assemble a group this fall to review and refine the points that are now being developed jointly. A conference in South Carolina organized by the American Association for Advancement in the Sciences entitled "Project on the Ethical and Legal Implications of Genetic Testing," helped generate advice, and identified some of the more controversial issues in design and conduct of genetic research that involves large groups of family members.Another "points to consider" effort concerns enrollment of women and minorities in research. The PHS has established a policy that members of these groups must be included in research projects unless there are valid scientific justifications for their exclusion which can be made on a project by project basis (ADAMHA/NIH Policy 1990; NIH/ADAMHA Policy 1990). OPRR has commissioned several scholarly papers to help in developing "points to consider" for IRBs as they balance issues of equitable selection of subjects and protection of these selected individuals. Concerns about enrolling women of childbearing age in research that may be harmful to a fetus, and liability issues frequently dominate discussion in this area. The papers will address ethical, legal, and statistical aspects of enrollment of minorities and women as well as provide a description of various practices and roles of IRBs in addressing goals of fair selection of participants and appropriate protections.OPRR is also working with the PHS Panel on Women, Adolescents and Children to produce a document, also in the form of "points to consider" guidance, concerning enrollment of children who are wards of the state in HIV-related research. Subpart D of the regulations for the protection of human subjects (45 CFR 46) specifically addresses research involving children who are wards of the state, including the special protections that must be provided. State and local officials who have authority to enroll foster care children in research have indicated a desire to obtain advice in this area.The IRB GuidebookA major project that is now being completed under contract to the Poynter Center at Indiana University is the IRB Guidebook. It will revise and expand the current IRB Guidebook produced in the 1980s... (shrink)

L'A. s'intéresse à la question des genres en théologie en prenant l'exemple d'une Encyclique du Pape Jean-Paul II sur la femme et sa dignité, Mulieris Dignitatem. La théologie féministe a donné, en effet, une importance nouvelle à cette question. Le document pontifical contient une analyse phénoménologique des différences entre les sexes et rejoint certaines analyses féministes. L'A. en profite pour soulever le problème de l'ordination des femmes au ministère presbytéral, et pour résoudre exhaustivement ce problème avec la substance de l'Encyclique.

Larry Shiner has risen to an impassioned defence against my criticisms of an iconic figure, claiming that I have ‘misrepresent[ed] Kristeller's central aim’ and therefore missed ‘the real shortcomings of Kristeller's essay’ and ‘obscure[d] substantive issues behind simplistic dichotomies’. These, and a series of disagreements over countless small details, take up the first part of his reply. He then proceeds to summarize his own book's achievements in correcting Kristeller's shortcomings. Shiner acknowledges difficulties in Kristeller's formulations, but accepts their purport and (...) actually expands the reach of Kristeller's thesis. Whatever else one might wish to say about these charges (which are quite impressive as a list but each disputable taken in turn), Shiner remains an unrepentant exponent of Kristeller's views. I realize that dogmas die hard, and it is only to be expected that if one challenges the central tenets of a legacy one will meet with entrenched reactions. Given the word-limit I have been allotted for my counter-reply, I will confine myself to the more substantive issues as these concern Kristeller's arguments, reserving for a possible future occasion any difficulties I may have with Shiner's own theses. My response will take the form of a series of questions followed by my own proposed answers. (shrink)

Simple models have played an important role in the discussion of foundational issues in statistical mechanics. Among them the spin-echo system is of particular interest since it can be realized experimentally. This has led to inferences being drawn about approaches to the foundations of statistical mechanics, particularly with respect to the use of coarse-graining. We examine these claims with the help of computer simulations.

An important contribution to the foundations of probability theory, statistics and statistical physics has been made by E. T. Jaynes. The recent publication of his collected works provides an appropriate opportunity to attempt an assessment of this contribution. * Review of E. T. JAYNES (1983): Papers on Probability, Statistics and Statistical Physics. Edited by R. D. Rosenkrantz. D. Reidel Publishing Company. US $49.50. Pp. xxiv + 434. We are grateful to Harvey Brown, Kenneth Denbigh, Udi Makov and Oliver Penrose for (...) their valuable criticisms of this paper. (shrink)

Lexical Semantics is about the meaning of words. Although obviously a central concern of linguistics, the semantic behaviour of words has been unduly neglected in the current literature, which has tended to emphasize sentential semantics and its relation to formal systems of logic. In this textbook D. A. Cruse establishes in a principled and disciplined way the descriptive and generalizable facts about lexical relations that any formal theory of semantics will have to encompass. Among the topics covered in depth are (...) idiomaticity, lexical ambiguity, synonymy, hierarchical relations such as hyponymy and meronymy, and various types of oppositeness. Syntagmatic relations are also treated in some detail. The discussions are richly illustrated by examples drawn almost entirely from English. Although a familiarity with traditional grammar is assumed, readers with no technical linguistic background will find the exposition always accessible. All readers with an interest in semantics will find in this original text not only essential background but a stimulating new perspective on the field. (shrink)

Background: Clinical genomic implementation studies pose challenges for informed consent. Consent forms often include complex language and concepts, which can be a barrier to diverse enrollment, and these studies often blur traditional research-clinical boundaries. There is a move toward self-directed, web-based research enrollment, but more evidence is needed about how these enrollment approaches work in practice. In this study, we developed and evaluated a literacy-focused, web-based consent approach to support enrollment of diverse participants in an ongoing clinical genomic implementation study. (...) Methods: As part of the Cancer Health Assessments Reaching Many (CHARM) study, we developed a web-based consent approach that featured plain language, multimedia, and separate descriptions of clinical care and research activities. CHARM offered clinical exome sequencing to individuals at high risk of hereditary cancer. We interviewed CHARM participants about their reactions to the consent approach. We audio recorded, transcribed, and coded interviews using a deductively and inductively derived codebook. We reviewed coded excerpts as a team to identify overarching themes. Results: We conducted 32 interviews, including 12 (38%) in Spanish. Most (69%) enrolled without assistance from study staff, usually on a mobile phone. Those who completed enrollment in one day spent an average of 12 minutes on the consent portion. Interviewees found the information simple to read but comprehensive, were neutral to positive about the multimedia support, and identified increased access to testing in the study as the key difference from clinical care. Conclusions: This study showed that interviewees found our literacy-focused, web-based consent approach acceptable; did not distinguish the consent materials from other online study processes; and valued getting access to testing in the study. Overall, conducting empirical bioethics research in an ongoing clinical trial was useful to demonstrate the acceptability of our novel consent approach but posed practical challenges. (shrink)

« La mesure est le plus grand des biens » et « rien de trop » apparaissent dans les sentences attribuées aux Sept Sages de l’Antiquité Grecque. Elles font état d’une sagesse qui blâme l’excès et invite à la modération. Les échos de ces propos résonnent dans différentes périodes de l’Antiquité et chez des auteurs appartenant aux traditions les plus variées, parmi lesquels se trouve notamment Démocrite. Nombreux sont en effet les fragments qui attestent de sa condamnation des excès, de (...) sa réflexion critique sur les richesses et de son éloge de la modération et de l’équilibre entendus comme conditions du bien-être et de l’action bonne. « La juste proportion est belle en toutes choses » (DK 68 B 102), proclame le philosophe. Cette juste proportion est érigée en condition pour atteindre la « bonne humeur » ( euthymiê ) et le « bien-être » ( euestô ). La réflexion de Démocrite se fonde sur une sorte de principe économique qui s’exprime par la notion de « mesure » ( metriotês ). La capacité à être modéré est aussi le signe distinctif de l’être humain bien accompli (DK 68 B 70), et s’oppose aux différentes formes de l’avidité. Lorsque l’on examine les fragments qui traitent de ce sujet, l’on constate que le philosophe a dressé un inventaire qui prend en compte les domaines les plus divers de la vie. Il est en effet question de la mesure aussi bien dans le cadre des affections comme le plaisir et le désir, que dans celui de la satisfaction de nos besoins élémentaires. Il en est également question pour ce qui est de notre attitude à l’égard des biens matériels et des richesses. Dans cet article nous avons choisi de faire porter l’attention sur la réflexion du philosophe sur les richesses et les biens matériels, en prenant tout particulièrement en compte sa mise en cause du désir dans l’économie de la vie humaine. Classification JEL : B1. (shrink)

L’article procède à un cheminement en quatre étapes : la première traite de la question de la mesure économique des productions nanométriques, dans une dynamique de filière et de convergence multidisciplinaire, champ d’étude de la méso-économie ; la seconde fait référence aux origines de l’approche mercantiliste de l’économie et à ses conséquences sur l’économie politique des matériaux avancés, procédés et services du domaine des nanotechnologies et matériaux avancés manufacturés ; la troisième étape recherchera les points d’appui sur lesquels l’économie politique (...) fait porter ses efforts pour développer la production et les échanges induits par les nanosciences et techniques en s’appuyant sur deux exemples ; la quatrième et dernière étape examine les barrières réelles au développement économique induit par les nanotechnologies, telles que les conflits d’intérêts entre acteurs autour de la question de la traçabilité les ont progressivement révélées dans les dialogues entre parties prenantes. (shrink)

Two mechanisms are available for the repair of DNA double‐strand breaks (DSBs) in eukaryotic cells: homology directed repair (HDR) and non‐homologous end‐joining (NHEJ). While NHEJ is not restricted to a particular phase of the cell cycle, it is incapable of accurately repairing DBSs that have suffered a loss or gain of nucleotide sequence information. In contrast, HDR achieves accurate repair of such DSBs by use of a sister chromatid as a DNA template, but is restricted to cell cycle phases (S/G2) (...) when such templates are available. In this scheme, G1 cells appear to lack a mechanism for the accurate repair of certain DSBs, and an ability to use alternative templates would be highly advantageous. Considered here, therefore, is the possibility that RNA transcripts are used as templates for HDR. Potential mechanisms for transcript‐templated HDR, and ways in which it might be detected, are presented. BioEssays 28:78–83, 2006. © 2005 Wiley Periodicals, Inc. (shrink)

Western Buddhist travel narratives are autobiographical accounts of a journey to a Buddhist culture. Dozens of such narratives have since the 1970s describe treks in Tibet, periods of residence in a Zen monastery, pilgrimages to Buddhist sites and teachers, and other Asian odysseys. The best known of these works is Peter Matthiessen's The Snow Leopard; further reflections emerge from thirty writers including John Blofeld, Jan Van de Wetering, Thomas Merton, Oliver Statler, Robert Thurman, Gretel Ehrlich, and Bill Porter. The (...) Buddhist concept of 'no-self' helps these authors interpret certain pivotal experiences of 'unselfing' and is also a catalyst that provokes and enables such events. The writers' spiritual memoirs describe how their journeys brought about a new understanding of Buddhist enlightenment and so transformed their lives. Showing how travel can elicit self-transformation, this book is a compelling exploration of the journeys and religious changes of both individuals and Buddhism itself. (shrink)

"This volume on a provocative set of topics presents papers from the 1997 conference on Religion and Sexuality at Roehampton Institute London. The papers do not confine themselves to contemporary discussion of the topics concerned, but range widely in their discourse and discuss this relationship in social, theological and political contexts."--Bloomsbury Publishing.

Revisiting African philosophy’s classic questions, D. A. Masolo advances understandings of what it means to be human—whether of African or other origin. Masolo reframes indigenous knowledge as diversity: How are we to understand the place and structure of consciousness? How does the everyday color the world we know? Where are the boundaries between self and other, universal and particular, and individual and community? From here, he takes a dramatic turn toward Africa’s current political situation and considers why individual rights and (...) freedoms have not been recognized, respected, demanded, or enforced. Masolo offers solutions for containing socially destructive conduct and antisocial tendencies by engaging community. His unique thinking about community and the role of the individual extends African philosophy in new, global directions. (shrink)